Pickens County Real Estate View 462 listings HomeGuidesPickens County With an estimated population on 93,894 residents, Pickens County offers beautiful mountain views, crisp and clean air, and rustic charm. Lake Keowee is easily accessible from Pickens County, along with many state parks and camping sites. Guides Oconee CountyAnderson CountyPickens CountyLake KeoweeLake HartwellLakefrontSenecaClemsonAndersonThe Cliffs & Reserve CommunitiesLots & LandCondos & Townhomes